Rybelsus vs Ozempic vs Wegovy: Which Is Best for Weight Loss?

Craig Sorkin, DNP, APN is a board certified Family Nurse Practitioner with over 15 years experience. He received his Undergraduate and Graduate degrees from William Paterson University and his doctoral degree from Drexel University. He has spent his career working in the Emergency Room and Primary Care. The last 6 years of his career have been dedicated to the field of digital medicine. He has created departments geared towards this specialized practice as well as written blogs and a book about the topic. It’s also important to note that there’s currently no generic form of Rybelsus.

It belongs to a class of drugs known as glucagon-like peptide-1 (GLP-1) receptor agonists. Rybelsus is the only oral form of this powerful diabetes and weight loss medication. It has been shown to grant both weight loss and blood sugar improvementsin many different populations, both alone and in combination with other diabetes drugs. Ozempic, like Rybelsus, contains semaglutide as its active ingredient. It works by controlling blood sugar levels and slowing down digestion. Rybelsus is not approved by the FDA to be prescribed for weight loss.

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Rybelsus (semaglutide) is an oral medicine that is used to improve blood sugar control in adults over the age of 18 with type 2 diabetes. It may be prescribed as first-line therapy in addition to diet and exercise or in addition to other medications typically used for type 2 diabetes. Rybelsus can’t match these results — at least not at the approved doses — and it hasn’t yet been tested as a weight-loss medication for people without type 2 diabetes. A clinical trial has shown that Rybelsus helps lower blood sugar more than a placebo (treatment with no active drug).

• It’s important to note that self-adjusting the dosage or abruptly discontinuing the medication can lead to adverse effects and may not produce the desired results.
• Below are commonly used dosages, but always take the dosage that your doctor prescribes.
• This can make Rybelsus less effective in managing your blood sugar.
• While Rybelsus is safe and effective for most patients, it can cause side effects in some people.

Like Rybelsus, Ozempic stimulates insulin secretion after eating and prevents your liver from making and releasing too much glucose, explains Dr. Comite. “It also slows gastric emptying (the time it takes food to leave the intestines) so you feel full longer,” she says. But it’s not currently prescribed to reduce the risk of these problems, either. Rybelsus may not be right for you if you have certain medical conditions or other factors that affect your health.

What is the Rybelsus dosage for weight loss?

Both Rybelsus and Ozempic are manufactured by the drug company Novo Nordisk, says Dr. Comite. Their main differences are the route of administration, frequency and strength. You can learn more about diabetes and its treatment options by subscribing to the Healthline diabetes newsletter. Before taking Rybelsus, talk with your doctor about whether this drug is right for you. Precautions and considerations for its use are described below. It’s unknown whether any herbs or natural products interact with Rybelsus.

Furthermore, 89.2% of the oral semaglutide group achieved a weight loss of 5% or more, compared to only 24.5% in the placebo group. Novo Nordisk, the pharmaceutical company behind Rybelsus, also manufactures Ozempic and Wegovy. These drugs share the same active ingredient as Rybelsus, a compound called semaglutide. Adds Dr. Levy, “Rybelsus appears to be safe although rybelsus 7mg there was a finding of increase benign skin tumors, which we will need to keep studying.” It increases the amount of insulin that is released from the pancreas and slows food leaving the stomach after eating to suppress appetite and speed weight loss. To get the best possible weight loss outcome, it’s important to choose a medication that works well for your needs.

If you’re trying to regain weight that you’ve lost, avoid eating empty calories. Instead, try to choose foods that are high in calories and nutrients. But weight loss from nausea, vomiting, and diarrhea may not be safe for you.